IBT Bioservices SARS-COV-2, Virus Like Particles (Ha-Cov2) Delta Plus (Ay4.2)

IBT Bioservices SARS-COV-2, Virus Like Particles (Ha-Cov2) Delta Plus (Ay4.2)

Summary

• SARS-CoV-2, Virus Like Particles (Ha-CoV2) Delta Plus (AY4.2): hybrid alpha-pseudovirus for SARS-CoV-2 (Ha-CoV2) for strain Delta Plus (AY4.2) The hybrid alpha-pseudovirus for SARS-CoV-2 (Ha-CoV-2) is a newly developed SARS-CoV-2 virus-like particle (VLP) that encapsulates an alphavirus-derived RNA genome for rapid report expression (luciferase or GFP) in target cells (Hetrick et al., 2022). Different from commonly used S protein pseudotyped lenti- or vesicular stomatitis virus (VSV)-pseudoviruses, Ha-CoV-2 is assembled with all 4 structural proteins (S, M, N, and E) of SARS-CoV-2, and contains a reporter genome derived from an alphavirusbased vector for rapid (6 hours) and robust expression of reporter genes. The alphavirus vector does not contain any of the structural proteins from the authentic virus and the alpha-pseudovirus particles are single-cycle. Notes & Usage Guidelines: Spike Mutations: Spike T19R, Spike T95I, Spike G142D, Spike Y145H, Spike E156G, Spike del157/158, Spike A222V, Spike L452R, Spike T478K, Spike D614G, Spike P681R, Spike D950N Size: 25 X 200 µL ~100 wells/96 well plate or 60x Conc. 5 x 100 µL Reporter: Available with Firefly luciferase, GFP, or RFP Intended for research use only, not for human, therapeutic, or diagnostic applications.

Overview

Properties

• Form: Liquid
• Formulation: Available upon request
• Storage: -80°C
• Concentration: 1X Concentrated

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