Phospho-JAK3 (Tyr785) Polyclonal Antibody
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Phospho-JAK3 (Tyr785) Polyclonal Antibody
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| SKU # | E-AB-21215 |
| Reactivity | Human,  Mouse,  Rat |
| Host | Rabbit |
| Applications | WB,  IHC-p |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human,  Mouse,  Rat |
| Applications | WB,  IHC-p |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from human JAK3 around the phosphorylation site of Tyr785 |
| Synonyms | EC 2.7.10.2,  JAK 3,  JAK L,  JAK-3,  JAK3,  JAK3 HUMAN,  JAKL,  Jak3,  Janus Kinase3,  Janus kinase 3,  Janus kinase 3 (a protein tyrosine kinase,  L JAK,  L-JAK,  LJAK,  Leukocyte janus kinase,  Protein tyrosine kinase leukocyte,  Tyrosine protein kinase JAK3,  Tyrosine-prote,  leukocyte) |
| Swissprot | |
| Calculated MW | 125 kDa |
| Observed MW | 125 kDa |
| Cellular Localization | Endomembrane system. Wholly intracellular, possibly membrane associated. |
| Tissue Specificity | In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer,  Epigenetics and Nuclear Signaling,  Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
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Background Â
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).