Phospho-IRS1 (Ser636) Polyclonal Antibody
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Phospho-IRS1 (Ser636) Polyclonal Antibody
| SKU # | E-AB-20908 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC-p, IF |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC-p, IF |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from human IRS-1 around the phosphorylation site of Ser636 |
| Synonyms | HIRS 1, HIRS1, IRS 1, IRS-1, IRS1, Insulin receptor substrate 1, OTTHUMP00000164234 |
| Swissprot | |
| Calculated MW | 132 kDa |
| Observed MW | 150 kDa |
| Cellular Localization | Cytosol, Nucleus, Plasma Membrane, caveola, insulin receptor complex, plasma membrane, Other locations: cytoplasm, intracellular membrane-bounded organelle. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
| IF | 1:200-1:1000 |
Background
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.