Phospho-Glucocorticoid Receptor (Ser211) Polyclonal Antibody
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Phospho-Glucocorticoid Receptor (Ser211) Polyclonal Antibody
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| SKU # | E-AB-21144 |
| Reactivity | Human,  Mouse,  Rat |
| Host | Rabbit |
| Applications | WB,  IHC-p |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human,  Mouse,  Rat |
| Applications | WB,  IHC-p |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from human GR around the phosphorylation site of Ser211 |
| Synonyms | GCCR,  GCR,  GCRST,  GR,  GRL,  Glucocorticoid receptor,  Grl1,  Nuclear receptor subfamily 3 group C member 1,  glucocorticoid nuclear receptor variant 1,  group C,  member 1 (glucocorticoid receptor),  nr3c1,  nuclear receptor subfamily 3 |
| Swissprot | |
| Calculated MW | 86 kDa |
| Observed MW | 95 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand, nuclear after ligand-binding and Nucleus. Localized largely in the nucleus. |
| Tissue Specificity | Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer,  Epigenetics and Nuclear Signaling,  Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
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Background Â
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.