PARD3 Polyclonal Antibody
Couldn't load pickup availability
Still have questions? Ask our experts!
PARD3 Polyclonal Antibody
| SKU # | E-AB-40193 |
| Reactivity | Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant Rat Partitioning defective 3 homolog protein |
| Abbre | PARD3A |
| Synonyms | ASIP, Atypical PKC isotype specific interacting protein, Atypical PKC isotype-specific-interacting protein, Baz, CTCL tumor antigen se2-5, Coagulation factor II receptor-like 2, F2rl2, PAR-3, agouti signaling protein, bazooka, par-3 family cell polarity regulator a |
| Swissprot | |
| Calculated MW | 151 kDa |
| Observed MW | 151 kDa |
| Cellular Localization | Endomembrane system. Cell junction. Cell junction>tight junction. Cell membrane. Cytoplasm>cell cortex. Cytoplasm>cytoskeleton. Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.PARD3 (Par-3 Family Cell Polarity Regulator) is a Protein Coding gene. Diseases associated with PARD3 include Gamma Heavy Chain Disease and Enamel Caries. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Ras signaling pathway. GO annotations related to this gene include protein phosphatase binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is PARD3B.