ITGA2B Monoclonal Antibody
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ITGA2B Monoclonal Antibody
| SKU # | E-AB-22101 |
| Reactivity | Human |
| Host | Mouse |
| Applications | IHC-p |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-p |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide |
| Abbre | CD41 |
| Synonyms | BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GPalpha IIb, GT, GTA, HPA3, ITA2B, ITGAB, Integrin, Integrin alpha 2b, Integrin alpha IIb, Integrin alpha-IIb light chain, Itga2b, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41, antigen CD41), form 2, platelet |
| Swissprot | |
| Cellular Localization | Membrane. |
| Tissue Specificity | Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells |
| Clone No. | 5D1 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-200 |
Background
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.