IRF4 Polyclonal Antibody
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IRF4 Polyclonal Antibody
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| SKU # | E-AB-13342 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human IRF4 |
| Abbre | IRF4 |
| Synonyms | IRF 4,  IRF-4,  IRF4,  Interferon regulatory factor 4,  Irf4,  LSIRF,  Lymphocyte specific IRF,  Lymphocyte specific interferon regulatory factor,  Lymphocyte-specific interferon regulatory factor,  MUM 1,  MUM1,  Multiple myeloma oncogene 1,  NF EM5,  NF-EM5,  NFEM5,  PU.1 interactio |
| Swissprot | |
| Calculated MW | 52 kDa |
| Cellular Localization | Nucleus. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer,  Epigenetics and Nuclear Signaling,  Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
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Background
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.