IL37 Polyclonal Antibody Reactivity Human
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IL37 Polyclonal Antibody Reactivity Human
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| SKU # | E-AB-52019 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human IL37 |
| Abbre | IL37 |
| Synonyms | FIL,  IL1F,  IL1H,  IL-1F,  IL1RP,  IL-1RP,  IL37,  FIL1,  FIL1(ZETA),  FIL1Z,  IL-1F7,  IL-1H,  IL-1H4,  IL-1RP1,  IL-37,  IL1F7,  IL1H4,  IL1RP1,  FIL1 zeta,  IL 1 zeta,  IL 1F7,  IL 1F7b (IL 1H4,  IL 1H,  IL 1H4,  IL 1RP1,  IL 1RP1),  IL 1X,  IL 1X protein,  IL-1 zeta,  IL1F7 (canonical product IL 1F7b),  IL-1X,  interleukin 1 family,  Interleukin 1 family member 7,  Interleukin 1 homolog 4,  Interleukin 1 related protein,  Interleukin 1 superfamily z,  Interleukin 1 zeta,  Interleukin 37,  Interleukin-1 family member 7,  Interleukin-1 homolog 4,  Interleukin-1 zeta,  Interleukin-1-related protein,  Interleukin-23,  member 7 (zeta) |
| Swissprot | |
| Cellular Localization | Cytoplasm>cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation. |
| Concentration | 1.44 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer,  Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:20-1:100 |
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Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. IL37 (Interleukin 37) is a Protein Coding gene. Diseases associated with IL37 include Rheumatoid Arthritis. Among its related pathways are Innate Immune System and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL36G.