CAV1 Polyclonal Antibody Host Rabbit
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CAV1 Polyclonal Antibody Host Rabbit
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| SKU # | E-AB-30778 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB,  IHC-p,  IF |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC-p, IF |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Caveolin-1 |
| Abbre | Caveolin-1 |
| Synonyms | 22 kD,  BSCL3,  CAV,  CAV1,  CGL3,  Caveolin 1 caveolae protein 22kDa,  Caveolin-1,  Caveolin1,  LCCNS,  MSTP085,  OTTHUMP00000025031,  PPH3,  VIP 21,  VIP21,  caveolae protein,  caveolin 1 alpha isoform,  caveolin 1 beta isoform,  cell growth-inhibiting protein 32 |
| Swissprot | |
| Calculated MW | 20 kDa |
| Observed MW | 25 kDa |
| Cellular Localization | Golgi apparatus membrane. Cell membrane. Membrane>caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer,  Cardiovascular,  Metabolism,  Signal Transduction,  Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-2000 |
| IHC | 1:50-300 |
| IF | 1:50-300 |
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Background
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.