CASP9 Monoclonal Antibody
Regular price
$ 559.95
Couldn't load pickup availability
Still have questions? Ask our experts!
CASP9 Monoclonal Antibody
Â
| SKU # | E-AB-22035 |
| Reactivity | Human |
| Host | Mouse |
| Applications | WB,  IHC-p,  IF,  IP |
Â
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human |
| Applications | WB,  IHC-p,  IF,  IP |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide |
| Abbre | Caspase 9 |
| Synonyms | APAF-3,  APAF3,  Apoptosis related cysteine peptidase,  Apoptotic protease Mch-6,  Apoptotic protease-activating factor 3,  CASP-9,  CASP9,  Caspase 9 Dominant Negative,  Caspase 9 apoptosis related cysteine peptidase,  Caspase 9c,  Caspase-9,  Caspase-9 subunit p10,  ICE |
| Swissprot | |
| Calculated MW | 46 kDa |
| Observed MW | 47-51 kDa |
| Cellular Localization | Cytosol, apoptosome, cytosol, Mitochondrion, Nucleus, Other locations: protein complex. |
| Tissue Specificity | Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer,  Cell Biology,  Metabolism |
| Clone No. | 3I3 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Â
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-300 |
| IF | 1:50-1:200 |
| IP | 1:100-1:300 |
Â
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.