BBC3 Polyclonal Antibody Host Rabbit
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BBC3 Polyclonal Antibody Host Rabbit
| SKU # | E-AB-40332 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human Bcl-2-binding component 3 protein |
| Abbre | BBC3 |
| Synonyms | BBC 3, BBC3, BCL 2 binding component 3, BCL2 binding component 3, Bbc3, Bcl-2-binding component 3, JFY 1, JFY-1, JFY1, PUMA alpha, PUMA/JFY1, p53 Upregulated Modulator of Apoptosis, p53 up regulated modulator of apoptosis, p53 up-regulated modulator of apoptosis |
| Swissprot | |
| Calculated MW | 21 kDa |
| Observed MW | 26 kDa |
| Cellular Localization | Mitochondrion |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1000 |
| IHC | 1:100-1:200 |
Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.