PERK Polyclonal Antibody Host Rabbit
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PERK Polyclonal Antibody Host Rabbit
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| SKU # | E-AB-32546 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC-p, IF |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC-p, IF |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from the N-terminal region of human PERK |
| Abbre | PERK |
| Synonyms | DKFZp781H1925,  E2AK3,  EC 2.7.11.1,  Eif2ak3,  Eukaryotic translation initiation factor 2 alpha kinase 3,  Eukaryotic translation initiation factor 2-alpha kinase 3,  HRI,  Heme regulated EIF2 alpha kinase,  HsPEK,  Pancreatic eIF2 alpha kinase,  Pancreatic eIF2-alpha kinas |
| Swissprot | |
| Calculated MW | 125 kDa |
| Observed MW | 125 kDa
|
| Cellular Localization | Endoplasmic reticulum membrane. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer,  Epigenetics and Nuclear Signaling,  Metabolism |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
| IF | 1:200-1:1000 |
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Background
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.