ITGA2B Monoclonal Antibody
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ITGA2B Monoclonal Antibody
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| SKU # | E-AB-22101 |
| Reactivity | Human |
| Host | Mouse |
| Applications | IHC-p |
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Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-p |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide |
| Abbre | CD41 |
| Synonyms | BDPLT16,  BDPLT2,  CD41,  CD41B,  GP2B,  GPIIb,  GPalpha IIb,  GT,  GTA,  HPA3,  ITA2B,  ITGAB,  Integrin,  Integrin alpha 2b,  Integrin alpha IIb,  Integrin alpha-IIb light chain,  Itga2b,  alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex,  antigen CD41,  antigen CD41),  form 2,  platelet |
| Swissprot | |
| Cellular Localization | Membrane. |
| Tissue Specificity | Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer,  Cardiovascular,  Immunology,  Signal Transduction,  Stem Cells |
| Clone No. | 5D1 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-200 |
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Background
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.