EIF2 alpha Polyclonal Antibody
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EIF2 alpha Polyclonal Antibody
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| SKU # | E-AB-31295 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Applications | WB, IHC-p, IF |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IHC-p, IF |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from human eIF2α around the non-phosphorylation site of Ser51. |
| Abbre | eIF2α |
| Synonyms | EIF 2,  EIF 2 alpha,  EIF 2A,  EIF 2alpha,  EIF-2alpha,  EIF2,  EIF2 alpha,  EIF2A,  EIF2S1,  Eukaryotic translation initiation fa,  Eukaryotic translation initiation factor 2 subunit 1 alpha,  Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa,  eIF-2-alpha,  eIF-2A |
| Swissprot | |
| Calculated MW | 36 kDa |
| Observed MW | 38 kDa |
| Cellular Localization | Cytoplasmic granule. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer,  Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
| IF | 1:50-1:200 |
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Background
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.