CFL1 Polyclonal Antibody Reactivity Human
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CFL1 Polyclonal Antibody Reactivity Human
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| SKU # | E-AB-40164 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant human Homeobox protein Cofilin-1 protein |
| Abbre | Cofilin-1 |
| Synonyms | 18 kDa phosphoprotein,  CFL,  CFL 1,  CFL1,  COF1,  Cofilin,  Cofilin 1,  Cofilin 1 non muscle,  Cofilin non muscle isoform,  Cofilin-1,  HEL-S-15,  epididymis secretory protein Li 15,  non-muscle isoform,  p18 |
| Swissprot | |
| Calculated MW | 17 kDa |
| Observed MW | 17 kDa
|
| Cellular Localization | Nucleus matrix. Cytoplasm>cytoskeleton. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer,  Cardiovascular,  Neuroscience,  Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:1000 |
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Background
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.