BECN1 Monoclonal Antibody
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BECN1 Monoclonal Antibody
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| SKU # | E-AB-22139 |
| Reactivity | Human,  Mouse,  Rat |
| Host | Mouse |
| Applications | WB,  IHC-p |
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Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human,  Mouse,  Rat |
| Applications | WB,  IHC-p |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide of Beclin-1 |
| Abbre | BECN1 |
| Synonyms | APG6,  ATG 6,  ATG6,  ATG6 autophagy related 6 homolog,  BECN 1,  BECN1,  Bcl-2-interacting protein beclin,  Beclin 1 (coiled coil moesin like BCL2 interacting protein),  Beclin 1 autophagy related,  Beclin-1,  Beclin1,  Becn1,  C,  Coiled coil myosin like BCL2 interacting protein |
| Swissprot | |
| Observed MW | 60 kDa |
| Cellular Localization | Golgi apparatus>trans-Golgi network membrane. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. |
| Tissue Specificity | Ubiquitous |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer,  Epigenetics and Nuclear Signaling,  Metabolism,  Microbiology,  Signal Transduction |
| Clone No. | 3C6 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-2000 |
| IHC | 1:100-200 |
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Background
Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.