{"product_id":"recombinant-rat-clec4a2-dcir-protein-his-tag","title":"Recombinant Rat CLEC4A2\/DCIR Protein (His Tag)","description":"\u003ch2\u003eRecombinant Rat CLEC4A2\/DCIR Protein (His Tag)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 67.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 38px;\"\u003e\n\u003ctd width=\"137\" style=\"width: 146.047px; height: 38px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"106\" style=\"height: 28.5pt; width: 387.953px;\"\u003ePKSR030276\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.5938px;\"\u003e\n\u003ctd style=\"width: 146.047px; height: 29.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 387.953px; height: 29.5938px;\"\u003e\u003cspan\u003eHEK293 Cells\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eDescription\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\n\u003ctable style=\"width: 104.745%; height: 274.313px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003eCLEC4A2, Dcir2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003eRat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\" width=\"170\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003eHEK293 Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003eGln70-Ser235\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003eQ5YIS1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003e21.8 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\"\u003eObserved Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003e32-36 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003eN-His\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 58.7812px;\"\u003e\n\u003ctd style=\"width: 30.5213%;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 69.1114%;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01 detail_section\" id=\"dt_tab2\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 254.719px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003e\u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003eGenerally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003eThis product is provided as lyophilized powder which is shipped with ice packs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003eLyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003ePlease refer to the printed manual for detailed information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cp data-end=\"427\" data-start=\"0\"\u003e \u003c\/p\u003e\n\u003cp data-end=\"427\" data-start=\"0\"\u003e \u003c\/p\u003e\n\u003cp data-end=\"427\" data-start=\"0\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-end=\"427\" data-start=\"0\"\u003eDendritic cell immunoreceptor (DCIR), also known as CLEC4A, CLECSF6, is a single-pass type II C-type lectin receptor expressed mainly in dendritic cells (DCs), which is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system. These type II receptors contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Additionally, DCIR can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"100μg","offer_id":40837555617850,"sku":"PKSR030276-100","price":962.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/Elabscience_3d163070-2ec3-4595-a8a0-46f46cdd30e4.jpg?v=1743417304","url":"https:\/\/www.msesupplies.com\/products\/recombinant-rat-clec4a2-dcir-protein-his-tag","provider":"MSE Supplies","version":"1.0","type":"link"}