{"product_id":"recombinant-human-trib2-trb2-protein-his-gst-tag","title":"Recombinant Human TRIB2\/TRB2 Protein (His \u0026 GST Tag)","description":"\u003ch2\u003eRecombinant Human TRIB2\/TRB2 Protein (His \u0026amp; GST Tag)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 29.5938px;\" width=\"503\" data-mce-style=\"height: 29.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\" data-mce-style=\"height: 10px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 10px;\" width=\"137\" data-mce-style=\"width: 164.547px; height: 10px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"106\" style=\"height: 10px; width: 367.453px;\"\u003ePKSH030394\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" data-mce-style=\"width: 164.547px; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 367.453px; height: 19.5938px;\" data-mce-style=\"width: 367.453px; height: 19.5938px;\"\u003e\u003cspan\u003eBaculovirus-Insect Cells\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\" data-mce-style=\"font-size: 0.875rem;\"\u003eDescription   \u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab1\" class=\"dt01\"\u003e\n\u003ctable class=\"pro-table\" style=\"width: 104.745%; height: 211.532px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003eC5FW, FLJ57420, GS3955, TRB2, TRIB2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\" width=\"170\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003eBaculovirus-Insect Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003eMet 1-Asn 343\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003eNP_067675.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003e66.0 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003eN-His \u0026amp; C-GST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 42.9265%;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 54.7812px;\"\u003e\n\u003ctd style=\"width: 42.9265%; height: 54.7812px;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 56.7214%; height: 54.7812px;\"\u003eThe specific activity was determined to be 22 nmol\/min\/mg using synthetic DYRKtide peptide (RRRFRPASPLRGPPK) as substrate.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv id=\"dt_tab2\" class=\"dt01 detail_section\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 305.5px;\" class=\"dtl_table\" data-mce-style=\"width: 100%; height: 305.5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.2974%; height: 19.5938px;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 69.3336%; height: 19.5938px;\"\u003e\u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.2974%; height: 39.1875px;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 69.3336%; height: 39.1875px;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\" data-mce-style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 30.2974%; height: 39.1875px;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 69.3336%; height: 39.1875px;\"\u003eStore at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 30.2974%; height: 58.7812px;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 69.3336%; height: 58.7812px;\"\u003eThis product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 97.9688px;\" data-mce-style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 30.2974%; height: 39.1875px;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 69.3336%; height: 39.1875px;\"\u003eSupplied as sterile solution of 50mM Tris, 100mM NaCl, 0.5mM PMSF, 0.5mM GSH, pH 8.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 50.7812px;\" data-mce-style=\"height: 50.7812px;\"\u003e\n\u003ctd style=\"width: 30.2974%; height: 17.5938px;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 69.3336%; height: 17.5938px;\"\u003eNot Applicable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eBackground\u003c\/span\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003eTribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). during anemia.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"50μg","offer_id":40695050829882,"sku":"PKSH030394-50","price":673.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/imy94K_b4ce8768-4ea2-4c93-92d4-fc12e99af1a8.jpg?v=1729752450","url":"https:\/\/www.msesupplies.com\/products\/recombinant-human-trib2-trb2-protein-his-gst-tag","provider":"MSE Supplies","version":"1.0","type":"link"}