{"product_id":"ide-monoclonal-antibody","title":"IDE Monoclonal Antibody","description":"\u003ch2\u003eIDE Monoclonal Antibody\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 68.7814px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"height: 10px; width: 156.719px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 387.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-22041\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eMouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eWB, IHC-p, IF\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 99.8182%; height: 512.391px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eWB,  IHC-p,  IF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eSynthetic Peptide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eIDE\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 34.5469px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eAbeta-degrading protease,  FLJ35968,  IDE,  Ide,  Insulin protease,  Insulin-degrading enzyme,  Insulinase,  Insulysin,  OTTHUMP00000020097\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"P14735\" href=\"https:\/\/www.uniprot.org\/uniprot\/P14735\" target=\"_blank\"\u003eP14735\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e118 kDa\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eCytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eProtein A purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eCancer,  Cell Biology,  Cardiovascular,  Metabolism,  Neuroscience,  Signal Transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eClone No.\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e1H4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 31.2857%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 58.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\"\u003eWB\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\"\u003e1:500-1:2000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\"\u003e1:50-300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.4596%;\"\u003eIF\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%;\"\u003e1:100-1:300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.\u003cbr\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40882208342074,"sku":"E-AB-22041-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40882208374842,"sku":"E-AB-22041-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40882208407610,"sku":"E-AB-22041-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40882208440378,"sku":"E-AB-22041-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-22041-3.jpg?v=1748257537","url":"https:\/\/www.msesupplies.com\/products\/ide-monoclonal-antibody","provider":"MSE Supplies","version":"1.0","type":"link"}