{"product_id":"apex1-polyclonal-antibody-store-at-20-c-1","title":"APEX1 Polyclonal Antibody Store at -20°C","description":"\u003ch2\u003eAPEX1 Polyclonal Antibody Store at -20°C\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 78.3752px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 196.188px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"102\" style=\"height: 19.5938px; width: 339.812px;\"\u003eE-AB-13896\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 196.188px; height: 19.5938px;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 339.812px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman,  Mouse,  Rat\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 196.188px; height: 19.5938px;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 339.812px; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 196.188px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 339.812px; height: 19.5938px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 99.8182%; height: 503.698px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eHuman,  Mouse,  Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eWB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eRecombinant protein of human APEX1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eAPEX1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 117.562px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eAP endonuclease 1,  AP endonuclease class I,  AP lyase,  APE,  APE 1,  APE-1,  APEN,  APEX,  APEX 1,  APEX nuclease,  APEX nuclease (multifunctional DNA repair enzyme) 1,  APEX1,  Apex nuclease 1,  Apurinic endonuclease,  Apurinic-apyrimidinic endonuclease 1,  Apurinic\/apyrimidi\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003e\n\u003cdiv\u003e\u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/P27695\" title=\"P27695\" class=\"text-primary mr-2\" target=\"_blank\"\u003eP27695\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003e36 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eMitochondrion. The cleaved APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress and Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003e0.2 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eCancer,  Cardiovascular,  Epigenetics and Nuclear Signaling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 13.8542px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.821%;\" width=\"170\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 67.6885%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 58.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.0549%; height: 19.5938px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.6391%; height: 19.5938px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.0549%; height: 19.5938px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 68.6391%; height: 19.5938px;\"\u003e\u003cspan\u003e1:500-1:2000\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eApurinic\/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40849868095546,"sku":"E-AB-13896-200","price":339.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40849868128314,"sku":"E-AB-13896-120","price":204.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40849868161082,"sku":"E-AB-13896-60","price":121.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/PolyclonalAntibody_6abe729f-a148-47da-a2cf-9cce0671bd1b.jpg?v=1744826917","url":"https:\/\/www.msesupplies.com\/products\/apex1-polyclonal-antibody-store-at-20-c-1","provider":"MSE Supplies","version":"1.0","type":"link"}