{"product_id":"tribioscience-cromakalim-atp-sensitive-potassium-channel-opener-tbi3228","title":"Tribioscience Cromakalim, ATP-Sensitive Potassium Channel Opener (TBI3228)","description":"\u003ch2\u003eTribioscience Cromakalim, ATP-Sensitive Potassium Channel Opener (TBI3228)\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eResearch Use Only. Not intended for human use.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cspan data-text-len=\"63\" class=\"zw-portion zw-text-portion\"\u003eBuy Tribioscience products from MSE Supplies at the best value.\u003c\/span\u003e\u003cspan class=\"EOP-readonly EOP\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1’-biphenyl]-3-yl)-benzenesulfonamide\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eC\u003csub\u003e19\u003c\/sub\u003eH\u003csub\u003e15\u003c\/sub\u003eCl\u003csub\u003e2\u003c\/sub\u003eNO\u003csub\u003e4\u003c\/sub\u003eS\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e424.30\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e943962-47-8\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003epowder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eSoluble in DMSO (up to 25 mg\/ml) or in Ethanol (up to 20 mg\/ml with warming)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e-20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e≥ 2 years.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eATP citrate lyase (ACL) inhibitor\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003ePotent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells. Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice. A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia. Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells. Reduces cell cycle progression in iBN cells.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 25 mg\/ml) or in Ethanol (up to 20 mg\/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.\u003c\/p\u003e","brand":"Tribioscience","offers":[{"title":"5 mg","offer_id":40972903350330,"sku":"TBI3228-5MG","price":83.95,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":40972903383098,"sku":"TBI3228-25MG","price":331.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/TBI3228.jpg?v=1754993327","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/tribioscience-cromakalim-atp-sensitive-potassium-channel-opener-tbi3228","provider":"MSE Supplies","version":"1.0","type":"link"}