{"product_id":"stat1-monoclonal-antibody-store-at-20-c","title":"STAT1 Monoclonal Antibody Store at -20°C","description":"\u003ch2\u003eSTAT1 Monoclonal Antibody Store at -20°C \u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 68.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd width=\"137\" style=\"height: 10px; width: 156.719px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 387.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-22203\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan class=\"cat reg_tag\"\u003e\u003cspan\u003eHuman,  Mouse,  Rat\u003c\/span\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eMouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eIHC-p\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pro-table\" style=\"width: 99.8182%; height: 519.985px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eHuman,  Mouse,  Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eIHC-p\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eSynthetic Peptide of STAT1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eSTAT1 Mouse (12E8)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 74.375px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eCANDF7,  DKFZp686B04100,  IMD31A,  IMD31B,  IMD31C,  ISGF 3,  ISGF-3,  OTTHUMP00000163552,  OTTHUMP00000165046,  OTTHUMP00000165047,  OTTHUMP00000205845,  Signal tr,  Signal transducer and activator of transcription 1 91kD,  Signal transducer and activator of transcription 1 91kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"P42224\" href=\"https:\/\/www.uniprot.org\/uniprot\/P42224\" target=\"_blank\"\u003eP42224\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 26.5469px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eCytoplasm. Nucleus. Translocated into the nucleus in response to IFN-gamma-induced tyrosine phosphorylation and dimerization.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eProtein A purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eCancer,  Epigenetics and Nuclear Signaling,  Signal Transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eClone No.\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003e12E8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 31.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 11.6825%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 11.6825%;\" width=\"170\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 88.127%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 58.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 35.4596%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 64.1793%; height: 19.5938px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\"\u003e1:100-200\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSignal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G\/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.\u003cbr\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40878436810810,"sku":"E-AB-22203-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40878436843578,"sku":"E-AB-22203-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40878436876346,"sku":"E-AB-22203-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40878436909114,"sku":"E-AB-22203-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-22203-2.jpg?v=1747977373","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/stat1-monoclonal-antibody-store-at-20-c","provider":"MSE Supplies","version":"1.0","type":"link"}