{"product_id":"recombinant-human-chga-protein-his-tag","title":"Recombinant Human CHGA Protein (His tag)","description":"\u003ch2\u003eRecombinant Human CHGA Protein (His tag)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 29.5938px;\" width=\"503\" data-mce-style=\"height: 29.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\" data-mce-style=\"height: 10px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 10px;\" width=\"137\" data-mce-style=\"width: 164.547px; height: 10px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 367.453px;\" width=\"106\" class=\"xl65\" height=\"38\"\u003ePDMH100095\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" data-mce-style=\"width: 164.547px; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 367.453px; height: 19.5938px;\" data-mce-style=\"width: 367.453px; height: 19.5938px;\"\u003e\u003cspan\u003eHEK293 Cells\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\" data-mce-style=\"font-size: 0.875rem;\"\u003eDescription    \u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab1\" class=\"dt01\"\u003e\n\u003ctable style=\"width: 100%; height: 176.344px;\" class=\"dtl_table\" data-mce-style=\"width: 100%; height: 176.344px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 39.5851%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003eCHGA, CgA, Chromogranin-A, Pituitary secretory protein I, SP-I\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 39.5851%;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 39.5851%;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003eHEK293 Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 39.5851%;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003eMet1-Gly457\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 39.5851%;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003eP10645\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 39.5851%;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003e50.2 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 39.5851%;\"\u003eObserved Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003e75 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 39.5851%;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003eC-His\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 39.5851%;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 60.0459%;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv id=\"dt_tab2\" class=\"dt01 detail_section\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 305.5px;\" class=\"dtl_table\" data-mce-style=\"width: 100%; height: 305.5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 27.7426%;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 71.8884%;\"\u003e\u0026gt; 95% as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 27.7426%;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 71.8884%;\"\u003ePlease contact us for more information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\" data-mce-style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 27.7426%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 71.8884%;\"\u003eGenerally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 27.7426%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 71.8884%;\"\u003eThis product is provided as lyophilized powder which is shipped with ice packs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 97.9688px;\" data-mce-style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 27.7426%;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 71.8884%;\"\u003eLyophilized from sterile PBS, pH 7.4.\u003cbr\u003eNormally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 50.7812px;\" data-mce-style=\"height: 50.7812px;\"\u003e\n\u003ctd style=\"width: 27.7426%;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 71.8884%;\"\u003eIt is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg\/mL. Concentration is measured by UV-Vis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003ch3\u003e\n\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan class=\"title\"\u003eBackground\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003eChromogranin A (CgA), also known as pituitary secretory protein I (SP-I), is a member of the granin family of regulated secretory proteins. CgA shares several protein characteristics common to the granin family: acidic isoelectric point, the capacity to bind calcium ions, the ability to form aggregates and multiple dibasic cleavage sites. Mature human CgA is 439 amino acids (aa) and contains 10 dibasic, proteolytic cleavage sites, capable of yielding several smaller peptides, each displaying a unique function. Mature human CgA shares 63% aa sequence identity with mouse and rat CgA. CgA is expressed exclusively in the secretory dense core granules of most normal and neoplastic neuroendocrine cells. Increased levels of CgA have been detected inpatients with neuroendocrine tumors as well as non-neuroendocrine tumors, hence CgA is an important serological marker for tumor diagnosis and monitoring tumorprogression\/regression. It has been demonstrated in mouse model that full-length CgA containing its C-terminal region can impair angiogenesis and tumor growth. In addition, CgA can bind to Secretogranin III to regulate the biogenesis of secretory granules.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"100μg","offer_id":40689422401594,"sku":"PDMH100095-100","price":708.95,"currency_code":"USD","in_stock":true},{"title":"20μg","offer_id":40689422434362,"sku":"PDMH100095-20","price":426.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/imy94K_e5415641-9028-4b19-bc7c-0f09b763f641.jpg?v=1729163092","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/recombinant-human-chga-protein-his-tag","provider":"MSE Supplies","version":"1.0","type":"link"}