{"product_id":"phospho-p70-s6-kinase-alpha-ser447-polyclonal-antibody","title":"Phospho-p70 S6 Kinase Alpha (Ser447) Polyclonal Antibody","description":"\u003ch2\u003ePhospho-p70 S6 Kinase Alpha (Ser447) Polyclonal Antibody\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 68.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd width=\"137\" style=\"height: 10px; width: 156.719px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 387.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-20959\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman,  Mouse,  Rat\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd width=\"170\" style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eRabbit\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eWB,  IHC-p\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pro-table\" style=\"width: 99.8182%; height: 535.735px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eHuman,  Mouse,  Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eWB,  IHC-p\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eSynthesized peptide derived from human p70 S6 kinase α around the phosphorylation site of Ser447\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 51.9688px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e70 kDa ribosomal protein S6 kinase 1,  KS6B1,  P70 S6 Kinase,  P70 beta 1,  alpha 1,  alpha 2,  p70 S6 kinase,  p70 S6 kinase alpha,  p70 S6K,  p70 S6K-alpha,  p70 S6KA,  p70 alpha,  p70 ribosomal S6 kinase alpha,  p70 ribosomal S6 kinase beta 1,  p70(S6,  p70(S6K) alpha\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.5469px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"P23443\" href=\"https:\/\/www.uniprot.org\/uniprot\/P23443\" target=\"_blank\"\u003eP23443\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e59 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e60 kDa\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eCytoplasm, Nucleus, Cytoplasm and Cell junction\u0026gt;synapse\u0026gt;synaptosome, Mitochondrion outer membrane.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 20.9688px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eTissue Specificity\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eWidely expressed\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eCancer,  Cell Biology,  Epigenetics and Nuclear Signaling,  Metabolism,  Signal Transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 31.4665%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 62.3126px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 23.125px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 35.4596%; height: 23.125px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 64.1793%; height: 23.125px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\"\u003eWB\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\"\u003e1:500-1:2000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\"\u003e1:100-1:300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e   \u003c\/p\u003e\n\u003cp\u003eP70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine\/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine\/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.\u003cbr\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40884442923066,"sku":"E-AB-20959-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40884442955834,"sku":"E-AB-20959-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40884442988602,"sku":"E-AB-20959-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40884443021370,"sku":"E-AB-20959-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-20959-1.jpg?v=1748349058","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/phospho-p70-s6-kinase-alpha-ser447-polyclonal-antibody","provider":"MSE Supplies","version":"1.0","type":"link"}