{"product_id":"nf-b-p65-monoclonal-antibody","title":"NFκB-p65 Monoclonal Antibody","description":"\u003ch2\u003eNFκB-p65 Monoclonal Antibody\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 68.7814px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"height: 10px; width: 156.719px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 387.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-22016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman,  Mouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eMouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 99.8182%; height: 512.391px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eHuman,  Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eWB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eSynthetic Peptide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eNFkB p65\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 34.5469px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eAvian reticuloendotheliosis viral (v rel) oncogene homolog A,  MGC131774,  NF kappa B p65delta3,  NFKB3,  Nuclear Factor NF Kappa B p65 Subunit,  Nuclear fact,  Nuclear factor NF-kappa-B p65 subunit,  Nuclear factor of kappa light polypeptide gene enhancer in B cells 3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"Q04206\" href=\"https:\/\/www.uniprot.org\/uniprot\/Q04206\" target=\"_blank\"\u003eQ04206\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003e60 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003e65 kDa\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eNucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalized with RELA in the nucleus upon TNF-alpha induction.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eProtein A purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eCancer,  Cell Biology,  Cardiovascular,  Epigenetics and Nuclear Signaling,  Metabolism,  Microbiology,  Neuroscience,  Signal Transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eClone No.\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003e9B4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 30.924%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.72%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 58.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.4596%;\"\u003eWB\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%;\"\u003e1:1000-3000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eProteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel,are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.\u003cbr\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40884117766202,"sku":"E-AB-22016-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40884117798970,"sku":"E-AB-22016-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40884117831738,"sku":"E-AB-22016-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40884117864506,"sku":"E-AB-22016-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-22016-1.jpg?v=1748324212","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/nf-b-p65-monoclonal-antibody","provider":"MSE Supplies","version":"1.0","type":"link"}