{"product_id":"kpna2-polyclonal-antibody-reactivity-human","title":"KPNA2 Polyclonal Antibody Reactivity Human","description":"\u003ch2\u003eKPNA2 Polyclonal Antibody Reactivity Human\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 83.3752px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 180.719px; height: 19.5938px;\"\u003e\u003cspan\u003eSKU #\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"height: 19.5938px; width: 363.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-52984\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 20.5938px;\"\u003e\n\u003ctd style=\"width: 180.719px; height: 20.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 363.281px; height: 20.5938px;\"\u003eHuman, \u003cspan\u003eMouse\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.5938px;\"\u003e\n\u003ctd style=\"width: 180.719px; height: 23.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 363.281px; height: 23.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 180.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 363.281px; height: 19.5938px;\"\u003e\u003cspan\u003eIHC\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 130%; height: 411.469px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eHuman, Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eIHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eFusion protein of human KPNA2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eKPNA2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eIMA1,  IPO A1,  IPOA 1,  IPOA1,  Importin alpha 1,  Importin alpha 2,  Importin alpha 2 subunit,  Importin alpha P1,  Importin subunit alpha-1,  KPNA2,  KPNA2 protein,  Karyopherin alpha 2,  Karyopherin alpha 2 RAG cohort 1,  Karyopherin alpha 2 subunit,  Karyopherin subunit alpha-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"P52292\" href=\"https:\/\/www.uniprot.org\/uniprot\/P52292\" target=\"_blank\"\u003eP52292\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eCytoplasm. Nucleus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003e1.08 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eAntigen affinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eCancer,  Immunology,  Signal Transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%;\"\u003eThe product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 41.8438px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 31.0469%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 68.5921%; height: 19.5938px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22.25px;\"\u003e\n\u003ctd style=\"width: 31.0469%; height: 22.25px;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 68.5921%; height: 22.25px;\"\u003e1:50-1:300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40911767470138,"sku":"E-AB-52984-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40911767502906,"sku":"E-AB-52984-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40911767535674,"sku":"E-AB-52984-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40911767568442,"sku":"E-AB-52984-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/Elabscience_c4b75ef4-a46d-4eed-8165-e92e65b6087e.jpg?v=1750314021","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/kpna2-polyclonal-antibody-reactivity-human","provider":"MSE Supplies","version":"1.0","type":"link"}