{"product_id":"ko-validated-her2-erbb2-polyclonal-antibody","title":"(KO Validated) HER2\/ErbB2 Polyclonal Antibody","description":"\u003ch2\u003e(KO Validated) HER2\/ErbB2 Polyclonal Antibody\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 96.7814px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 38px;\"\u003e\n\u003ctd style=\"height: 38px; width: 214.5px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 28.5pt; width: 329.5px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-93336\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 214.5px; height: 19.5938px;\" width=\"170\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 329.5px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 214.5px; height: 19.5938px;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 329.5px; height: 19.5938px;\"\u003e\u003cspan\u003eRabbit\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 214.5px; height: 19.5938px;\"\u003e\u003cspan\u003eApplications\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 329.5px; height: 19.5938px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table2\" style=\"width: 100%; height: 482.001px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eWB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 27.75px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eA synthetic peptide of human HER2\/ErbB2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eHER2\/ErbB2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eCD340, HER-2, HER-2\/neu, HER2, MLN 19, MLN19, NEU,   NGL, TKR1, erb-b2 receptor tyrosine kinase 2, ERBB2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003e\n\u003cdiv\u003e\u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/P04626\" title=\"P04626\" class=\"text-primary mr-2\" target=\"_blank\"\u003eP04626\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 31.1875px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003e62 kDa\/70 kDa\/97 kDa\/134 kDa\/136 kDa\/137 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003e185 kDa\n\u003cdiv class=\"position-relative\"\u003e\u003ca role=\"button\" data-toggle=\"collapse\" href=\"https:\/\/www.elabscience.com\/p\/ko-validated-her2-erbb2-polyclonal-antibody--e-ab-93336#collapseMW\" aria-expanded=\"true\" aria-controls=\"collapseMW\" class=\"text-secondary\" target=\"_blank\"\u003e\u003ci class=\"iconfont icon-question-circle fs_16\" aria-hidden=\"true\"\u003e\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eThe actual band is not consistent with the expectation.\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eCell membrane, Cytoplasm, Nucleus, Nucleus, Single-pass type I membrane protein, perinuclear region.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eCancer,  Immunology,  Signal Transduction,  Tags and Cell Markers\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.4079%;\" width=\"170\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 79.5314px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 27.0758%; height: 19.5938px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 72.5632%; height: 19.5938px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 27.0758%; height: 19.5938px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 72.5632%; height: 19.5938px;\"\u003e\u003cspan\u003e1:500-1:2000\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654\/Ile655, shown here. Amplification and\/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40872070905914,"sku":"E-AB-93336-200","price":722.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40872070938682,"sku":"E-AB-93336-120","price":524.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40872070971450,"sku":"E-AB-93336-60","price":398.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-93336.jpg?v=1747257029","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/ko-validated-her2-erbb2-polyclonal-antibody","provider":"MSE Supplies","version":"1.0","type":"link"}