{"product_id":"cul2-polyclonal-antibody-store-at-20-c","title":"CUL2 Polyclonal Antibody Store at -20°C","description":"\u003ch2\u003eCUL2 Polyclonal Antibody Store at -20°C\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 78.3752px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"137\" style=\"height: 19.5938px; width: 200.104px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 19.5938px; width: 346.562px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-15575\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 200.104px; height: 19.5938px;\" width=\"170\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 346.562px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman,  Mouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 200.104px; height: 19.5938px;\" width=\"170\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 346.562px; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 200.104px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 346.562px; height: 19.5938px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pro-table\" style=\"width: 134.126%; height: 343.094px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eHuman,  Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eWB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eSynthetic peptide of human CUL2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eCUL2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eCUL 2,  CUL-2,  CUL2,  Cul2,  Cullin-2,  MGC131970,  cullin 2,  cullin homolog 2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003e\n\u003cdiv\u003e\u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/Q13617\" title=\"Q13617\" class=\"text-primary mr-2\" target=\"_blank\"\u003eQ13617\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003e87 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eCytosol, Nucleus, nucleolus, nucleoplasm, Other locations: Cul2-RING ubiquitin ligase complex, VCB complex.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003e0.6 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eCancer,  Cell Biology\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 23.17%;\" width=\"170\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 76.4743%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 59.4688px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 39.875px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 31.0549%; height: 39.875px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 68.6391%; height: 39.875px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.0549%;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 68.6391%;\"\u003e\u003cspan\u003e1:500-1:2000\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHuman CUL2 is an ortholog of nematode cul2. Michel and Xiong (1998) identified human CUL2 cDNAs and reported that the predicted protein is 745 amino acids long.Core component of multiple cullin-RING-based ECS (ElonginB\/C-CUL2\/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, whicHuman, Mouseediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A\/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40868488446010,"sku":"E-AB-15575-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40868488478778,"sku":"E-AB-15575-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40868488511546,"sku":"E-AB-15575-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40868488544314,"sku":"E-AB-15575-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/PolyclonalAntibody_e1bf362d-a1d1-4cc9-a73f-d96d49dda663.jpg?v=1746806181","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/cul2-polyclonal-antibody-store-at-20-c","provider":"MSE Supplies","version":"1.0","type":"link"}