{"product_id":"camsap3-polyclonal-antibody-reactivity-mouse","title":"CAMSAP3 Polyclonal Antibody Reactivity Mouse","description":"\u003ch2\u003eCAMSAP3 Polyclonal Antibody Reactivity Mouse\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 69.7814px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"height: 10px; width: 180.719px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 363.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-52103\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 180.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 363.281px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman, Mouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 20.5938px;\"\u003e\n\u003ctd style=\"width: 180.719px; height: 20.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 363.281px; height: 20.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 180.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 363.281px; height: 19.5938px;\"\u003eIHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pro-table\" style=\"width: 130%; height: 411.469px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eHuman, Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eIHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eSynthetic peptide of human CAMSAP3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eCAMSAP3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 58.7812px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 58.7812px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 58.7812px;\"\u003emember 3,  CAMP3,  Calmodulin regulated spectrin associated protein family,  Calmodulin-regulated spectrin-associated protein 3,  KIAA1543,  NEZHA,  Protein Nezha\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"Q9P1Y5\" href=\"https:\/\/www.uniprot.org\/uniprot\/Q9P1Y5\" target=\"_blank\"\u003eQ9P1Y5\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 39.1875px;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 39.1875px;\"\u003eCell junction\u0026gt;adherens junction. Cytoplasm. Cytoplasm\u0026gt;cytoskeleton. Scattered in the cytoplasm. Localizes along zonula adherens only at mature cell-cell contacts.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003e1.32 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eAntigen affinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eCancer,  Signal transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 19.5938px;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 19.5938px;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 24.0997%; height: 39.1875px;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 75.6233%; height: 39.1875px;\"\u003eThe product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 42.75px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 21.375px;\"\u003e\n\u003ctd style=\"width: 39.6267%; height: 21.375px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 60.0122%; height: 21.375px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21.375px;\"\u003e\n\u003ctd style=\"width: 39.6267%; height: 21.375px;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 60.0122%; height: 21.375px;\"\u003e1:50-1:200\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKey microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391).\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40891007991866,"sku":"E-AB-52103-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40891008024634,"sku":"E-AB-52103-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40891008057402,"sku":"E-AB-52103-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40891008090170,"sku":"E-AB-52103-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/Elabscience_7ef767ff-b648-4d67-96d4-05495be19e49.jpg?v=1748670077","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/camsap3-polyclonal-antibody-reactivity-mouse","provider":"MSE Supplies","version":"1.0","type":"link"}