{"product_id":"brca1-polyclonal-antibody-store-at-20-c","title":"BRCA1 Polyclonal Antibody Store at -20°C","description":"\u003ch2\u003eBRCA1 Polyclonal Antibody Store at -20°C\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 70.297px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"height: 10px; width: 170.547px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 363.453px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-10188\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 170.547px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 363.453px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 170.547px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 363.453px; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21.1094px;\"\u003e\n\u003ctd style=\"height: 21.1094px; width: 170.547px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 363.453px; height: 21.1094px;\"\u003eIHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table2\" style=\"width: 100%; height: 476.766px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eIHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eRecombinant protein of human BRCA1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eBRCA1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 38.547px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eBRCA 1,  BRCA1,  BRCA1 DNA repair associated,  BRCA1\/BRCA2 containing complex subunit 1,  BRCA1\/BRCA2-containing complex,  BRCAI,  BRCC 1,  BRCC1,  Breast Cancer 1,  Breast Cancer 1 Early Onset,  Breast and ovarian cancer susceptibility protein 1,  Breast cance,  subunit 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"P38398\" href=\"https:\/\/www.uniprot.org\/uniprot\/P38398\" target=\"_blank\"\u003eP38398\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eCytoplasm, Nucleus, Localizes at sites of DNA damage at double-strand breaks (DSBs) and recruitment to DNA damage sites is mediated by the BRCA1-A complex.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 42.75px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003e0.3 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 31.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eCancer,  Cell Biology,  Epigenetics and Nuclear Signaling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 31.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.9853%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 55.3751px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 26.9325%; height: 19.5938px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 72.6999%; height: 19.5938px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21.1875px;\"\u003e\n\u003ctd style=\"width: 26.9325%; height: 21.1875px;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 72.6999%; height: 21.1875px;\"\u003e1:50-1:200\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40844175835194,"sku":"E-AB-10188-200","price":339.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40844175867962,"sku":"E-AB-10188-120","price":204.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40844175900730,"sku":"E-AB-10188-60","price":121.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/Elabscience_c24743e2-6dbb-4bb0-9dbd-49c391be5cb2.jpg?v=1744198329","url":"https:\/\/www.msesupplies.com\/en-gb\/products\/brca1-polyclonal-antibody-store-at-20-c","provider":"MSE Supplies","version":"1.0","type":"link"}