{"product_id":"tribioscience-st-034307-adenylate-cyclase-1-inhibitor-analgesic-activity-tbi1620","title":"Tribioscience ST-034307, Adenylate Cyclase 1 Inhibitor; Analgesic Activity (TBI1620)","description":"\u003ch2\u003eTribioscience ST-034307, Adenylate Cyclase 1 Inhibitor; Analgesic Activity (TBI1620)\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eResearch Use Only. Not intended for human use.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cspan class=\"zw-portion zw-text-portion\" data-text-len=\"63\"\u003eBuy Tribioscience products from MSE Supplies at the best value.\u003c\/span\u003e\u003cspan class=\"EOP-readonly EOP\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eC\u003csub\u003e10\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003eCl\u003csub\u003e4\u003c\/sub\u003eO\u003csub\u003e2\u003c\/sub\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e297.95\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e133406-29-8\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003epowder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eSoluble in DMSO (up to 30 mg\/ml) or in Ethanol (up to 6 mg\/ml)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eRT\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e≥ 1 year.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eAdenylate cyclase 1 inhibitor; Analgesic activity\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eA novel selective adenylyl cyclase 1 (AC1) inhibitor, IC\u003csub\u003e50\u003c\/sub\u003e=2.3 μM . Inhibits calcium\u003csup\u003e2+\u003c\/sup\u003e-stimulated cAMP accumulation in HEK cells stably transfected with AC1. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells.  It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation. Displays analgesic properties in a mouse model of inflammatory pain.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 30 mg\/ml) or in Ethanol (up to 6 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.\u003c\/p\u003e","brand":"Tribioscience","offers":[{"title":"5 mg","offer_id":40972147458106,"sku":"TBI1620-5MG","price":113.95,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":40972147490874,"sku":"TBI1620-25MG","price":436.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/TBI1620.jpg?v=1754908305","url":"https:\/\/www.msesupplies.com\/en-de\/products\/tribioscience-st-034307-adenylate-cyclase-1-inhibitor-analgesic-activity-tbi1620","provider":"MSE Supplies","version":"1.0","type":"link"}