{"product_id":"tribioscience-icilin-trpm8-channel-activator-tbi4380","title":"Tribioscience Icilin, TRPM8 Channel Activator (TBI4380)","description":"\u003ch2 class=\"product_title entry-title show-product-nav\"\u003eTribioscience Icilin, TRPM8 Channel Activator (TBI4380)\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eResearch Use Only. Not intended for human use.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cspan data-text-len=\"63\" class=\"zw-portion zw-text-portion\"\u003eBuy Tribioscience products from MSE Supplies at the best value.\u003c\/span\u003e\u003cspan class=\"EOP-readonly EOP\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAG 3-5\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eC\u003csub\u003e16\u003c\/sub\u003eH\u003csub\u003e13\u003c\/sub\u003eN\u003csub\u003e3\u003c\/sub\u003eO\u003csub\u003e4\u003c\/sub\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e311.29\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e36945-98-9\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003epowder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eSoluble in DMSO (up to 25 mg\/ml)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e-20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e≥ 1 year.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTRPM8 channel activator\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIcilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8). Agonist at TRPM8 (EC50 = 0.2 µM) and ANKTM1(TRPA1). Agonist effects require Ca2+ and are pH dependent.  Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 25 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.\u003c\/p\u003e\n\u003cdiv class=\"container\"\u003e\n\u003cdiv class=\"row main-content-wrap\"\u003e\n\u003cdiv class=\"main-content col-lg-12\"\u003e\n\u003cdiv class=\"content-area\" id=\"primary\"\u003e\u003cmain class=\"site-main\" id=\"content\"\u003e\n\u003cdiv class=\"product type-product post-4091 status-publish first instock product_cat-biochemical-assays product_cat-life-sciences has-post-thumbnail taxable shipping-taxable purchasable product-type-variable product-layout-default\" id=\"product-4091\"\u003e\n\u003cdiv id=\"product-tab\" class=\"woocommerce-tabs woocommerce-tabs-1jgzs022 resp-htabs\"\u003e\n\u003cdiv class=\"resp-tabs-container\"\u003e\n\u003cdiv aria-labelledby=\"tab_item-0\" id=\"tab-description\" class=\"tab-content resp-tab-content resp-tab-content-active\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/main\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Tribioscience","offers":[{"title":"10 mg","offer_id":40964371841082,"sku":"TBI4380-10MG","price":113.95,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":40964371873850,"sku":"TBI4380-50MG","price":427.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/TBI4380.jpg?v=1754285117","url":"https:\/\/www.msesupplies.com\/en-de\/products\/tribioscience-icilin-trpm8-channel-activator-tbi4380","provider":"MSE Supplies","version":"1.0","type":"link"}