{"product_id":"tert-polyclonal-antibody-store-at-20-c","title":"TERT Polyclonal Antibody Store at -20°C","description":"\u003ch2\u003eTERT Polyclonal Antibody Store at -20°C\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 82.3752px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"137\" style=\"height: 19.5938px; width: 179.719px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 19.5938px; width: 364.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-12512\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 179.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 364.281px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21.5938px;\"\u003e\n\u003ctd style=\"width: 179.719px; height: 21.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 364.281px; height: 21.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21.5938px;\"\u003e\n\u003ctd style=\"height: 21.5938px; width: 179.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 364.281px; height: 21.5938px;\"\u003eWB, IHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pro-table\" style=\"width: 99.8182%; height: 640.594px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003eWB, IHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003eSynthetic peptide of human TERT\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003eTERT\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 78.375px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 78.375px;\"\u003eCMM9,  DKCA2,  DKCB4,  EST2,  HEST2,  PFBMFT1,  TCS1,  TERT,  TP2,  TRT,  Telomerase associated protein 2,  Telomerase catalytic subunit,  Telomerase reverse transcriptase,  Telomerase-associated protein 2,  Telomere Reverse Transcriptase,  hTRT,  htert\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"O14746\" href=\"https:\/\/www.uniprot.org\/uniprot\/O14746\" target=\"_blank\"\u003eO14746\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 39.1875px;\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 39.1875px;\"\u003e127 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 156.75px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 156.75px;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 156.75px;\"\u003eNucleus\u0026gt;nucleolus. Nucleus\u0026gt;nucleoplasm. Nucleus. Chromosome\u0026gt;telomere. Cytoplasm. Nucleus\u0026gt;PML body. Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1\/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 27.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 27.1875px;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 27.1875px;\"\u003e1.1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 35.1875px;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 35.1875px;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 39.1875px;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 39.1875px;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 39.1875px;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 39.1875px;\"\u003eCancer,  Epigenetics and Nuclear Signaling,  Developmental Biology,  Stem Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 19.5938px;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 19.5938px;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 10px;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 10px;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 25.2888%; height: 39.1875px;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 74.5103%; height: 39.1875px;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 41.7188px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 31.0662%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 68.5662%; height: 19.5938px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22.125px;\"\u003e\n\u003ctd style=\"width: 31.0662%; height: 22.125px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 68.5662%; height: 22.125px;\"\u003e\u003cspan\u003e1:200-1:1000\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.0662%;\"\u003e\u003cspan\u003eIHC\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 68.5662%;\"\u003e\u003cspan\u003e1:25-1:100\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.\u003c\/span\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40863959253050,"sku":"E-AB-12512-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40863959285818,"sku":"E-AB-12512-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40863959318586,"sku":"E-AB-12512-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40863959351354,"sku":"E-AB-12512-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/Elabscience_81092863-9707-497b-9598-e72709cb76bd.jpg?v=1746419240","url":"https:\/\/www.msesupplies.com\/en-de\/products\/tert-polyclonal-antibody-store-at-20-c","provider":"MSE Supplies","version":"1.0","type":"link"}