{"product_id":"recombinant-human-mucin-1-muc-1-protein-fc-tag","title":"Recombinant Human Mucin-1\/MUC-1 Protein (Fc Tag)","description":"\u003ch2\u003eRecombinant Human Mucin-1\/MUC-1 Protein (Fc Tag)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 29.5938px;\" data-mce-style=\"height: 29.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\" data-mce-style=\"height: 10px;\"\u003e\n\u003ctd width=\"137\" style=\"width: 164.547px; height: 10px;\" data-mce-style=\"width: 164.547px; height: 10px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"106\" style=\"height: 10px; width: 367.453px;\" data-mce-style=\"height: 10px; width: 367.453px;\"\u003ePKSH030274\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" data-mce-style=\"width: 164.547px; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 367.453px; height: 19.5938px;\" data-mce-style=\"width: 367.453px; height: 19.5938px;\"\u003e\u003cspan\u003eHEK293 Cells\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\" data-mce-style=\"font-size: 0.875rem;\"\u003eDescription    \u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 176.344px;\" data-mce-style=\"width: 100%; height: 176.344px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" width=\"170\" data-mce-style=\"width: 45.0595%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003eBreast carcinoma-associated antigen DF3, CA 15-3, Cancer antigen 15-3, Carcinoma-associated mucin, Episialin, H23AG, KL-6, Krebs von den Lungen-6, MUC-1, Mucin-1, PEM, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial me\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" data-mce-style=\"width: 45.0595%;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" width=\"170\" data-mce-style=\"width: 45.0595%;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003eHEK293 Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" data-mce-style=\"width: 45.0595%;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003eMet 1-Gly 167\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" data-mce-style=\"width: 45.0595%;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003eNP_001018016.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" data-mce-style=\"width: 45.0595%;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003e42 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" data-mce-style=\"width: 45.0595%;\"\u003eObserved Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003e55-60 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" data-mce-style=\"width: 45.0595%;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003eC-hFc\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 45.0595%;\" data-mce-style=\"width: 45.0595%;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 54.5715%;\" data-mce-style=\"width: 54.5715%;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv class=\"dt01 detail_section\" id=\"dt_tab2\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 305.5px;\" data-mce-style=\"width: 100%; height: 305.5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 24.6404%;\" data-mce-style=\"width: 24.6404%;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 74.9906%;\" data-mce-style=\"width: 74.9906%;\"\u003e\u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 24.6404%;\" data-mce-style=\"width: 24.6404%;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 74.9906%;\" data-mce-style=\"width: 74.9906%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\" data-mce-style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 24.6404%;\" data-mce-style=\"width: 24.6404%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 74.9906%;\" data-mce-style=\"width: 74.9906%;\"\u003eGenerally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 24.6404%;\" data-mce-style=\"width: 24.6404%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 74.9906%;\" data-mce-style=\"width: 74.9906%;\"\u003eThis product is provided as lyophilized powder which is shipped with ice packs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 97.9688px;\" data-mce-style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 24.6404%;\" data-mce-style=\"width: 24.6404%;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 74.9906%;\" data-mce-style=\"width: 74.9906%;\"\u003eLyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 50.7812px;\" data-mce-style=\"height: 50.7812px;\"\u003e\n\u003ctd style=\"width: 24.6404%;\" data-mce-style=\"width: 24.6404%;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 74.9906%;\" data-mce-style=\"width: 74.9906%;\"\u003ePlease refer to the printed manual for detailed information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003ch3\u003e\n\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan class=\"title\"\u003eBackground\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003eMucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. MUC-1 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1 influences directly or indirectly the Ras\/MAPK pathway. MUC-1 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"100μg","offer_id":40692274298938,"sku":"PKSH030274-100","price":864.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/recombinant-human-mucin-1-muc-1-protein-fc-tag-100-g-elabscience-biotechnology-cell-assays-22372305928250.jpg?v=1752498023","url":"https:\/\/www.msesupplies.com\/en-de\/products\/recombinant-human-mucin-1-muc-1-protein-fc-tag","provider":"MSE Supplies","version":"1.0","type":"link"}