{"product_id":"recombinant-human-mep1a-ppha-protein-his-tag","title":"Recombinant Human MEP1A\/PPHA Protein (His Tag)","description":"\u003ch2\u003eRecombinant Human MEP1A\/PPHA Protein (His Tag)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 29.5938px;\" data-mce-style=\"height: 29.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\" data-mce-style=\"height: 10px;\"\u003e\n\u003ctd width=\"137\" style=\"width: 164.547px; height: 10px;\" data-mce-style=\"width: 164.547px; height: 10px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"106\" style=\"height: 19.5938px; width: 367.453px;\"\u003ePKSH031843\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" data-mce-style=\"width: 164.547px; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 367.453px; height: 19.5938px;\"\u003eHEK293 Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\" data-mce-style=\"font-size: 0.875rem;\"\u003eDescription\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\n\u003ctable style=\"width: 104.745%; height: 205.938px;\" class=\"pro-table\" data-mce-style=\"width: 104.745%; height: 270.312px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\" data-mce-style=\"height: 117.562px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 10px;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 10px;\"\u003ePPHA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 15.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 19.5938px;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 19.5938px;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 19.5938px;\" width=\"170\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 19.5938px;\"\u003eHEK293 Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 19.5938px;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 19.5938px;\"\u003eMet 1-Gln 601\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 19.5938px;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 19.5938px;\"\u003eNP_005579.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 39.1875px;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 39.1875px;\"\u003e67.7 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 39.1875px;\"\u003eObserved Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 39.1875px;\"\u003e80 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 19.5938px;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 19.5938px;\"\u003eC-His\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.6338%; height: 19.5938px;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 69.0141%; height: 19.5938px;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01 detail_section\" id=\"dt_tab2\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 305.5px;\" data-mce-style=\"width: 100%; height: 305.5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.1587%;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 82.4723%;\"\u003e\u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.1587%;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 82.4723%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\" data-mce-style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 17.1587%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 82.4723%;\"\u003eGenerally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 17.1587%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 82.4723%;\"\u003eThis product is provided as lyophilized powder which is shipped with ice packs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 97.9688px;\" data-mce-style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 17.1587%;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 82.4723%;\"\u003eLyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 50.7812px;\" data-mce-style=\"height: 50.7812px;\"\u003e\n\u003ctd style=\"width: 17.1587%;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 82.4723%;\"\u003ePlease refer to the printed manual for detailed information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003cspan\u003eBackground\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003eMeprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I membrane protein which belongs to thepeptidase M12A family. MEP1A contains oneEGF-like domain, oneMAM domain, and oneMATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ).\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"50μg","offer_id":40729757876282,"sku":"PKSH031843-50","price":1024.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/imy94K_ec13dfaf-1f13-4449-b643-ce451a778269.jpg?v=1733053315","url":"https:\/\/www.msesupplies.com\/en-de\/products\/recombinant-human-mep1a-ppha-protein-his-tag","provider":"MSE Supplies","version":"1.0","type":"link"}