{"product_id":"recombinant-human-il-8-cxcl8-protein-e-coli","title":"Recombinant Human IL-8\/CXCL8 Protein (E.coli)","description":"\u003ch2\u003eRecombinant Human IL-8\/CXCL8 Protein (E.coli)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 29.5938px;\" data-mce-style=\"height: 29.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\" data-mce-style=\"height: 10px;\"\u003e\n\u003ctd width=\"137\" style=\"width: 164.547px; height: 10px;\" data-mce-style=\"width: 164.547px; height: 10px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"106\" style=\"height: 10px; width: 367.453px;\"\u003ePKSH030277\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" data-mce-style=\"width: 164.547px; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 367.453px; height: 19.5938px;\" data-mce-style=\"width: 367.453px; height: 19.5938px;\"\u003e\u003cspan\u003eE.coli\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\" data-mce-style=\"font-size: 0.875rem;\"\u003eDescription    \u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 176.344px;\" data-mce-style=\"width: 100%; height: 176.344px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eCXCL, Interleukin, C-X-C motif chemokine, Chemokine (C-X-C motif) ligand, IL8\/CXCL, GCP, NAP, CXCL8, GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, 3-10C, AMCF-I, IL8\/CXCL8, K60, Interleukin-8, IL-8, Emoctakin, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Granulocyte chemotactic protein 1 (GCP-1), Monocyte-derived neutrophil chemotactic factor (MDNCF), (Ala-IL-8)77, (Ser-IL-8)72, 9E3, Beta thromboglobulin like protein, CEF-4, chemokine, CXC motif, GCP\/IL-8 protein I, GCP\/IL-8 protein II, GCP\/IL-8 protein III, GCP\/IL-8 protein IV, GCP\/IL-8 protein V, GCP\/IL-8 protein VI, Granulocyte chemotactic protein 1, IL-8(1-77), IL-8(9-77), IL8\/NAP1 form I, IL8\/NAP1 form II, IL8\/NAP1 form III, IL8\/NAP1 form IV, IL8\/NAP1 form V, IL8\/NAP1 form VI, Inteleukin 8, ligand 8, Lymphocyte-derived neutrophil-activating factor, MDNCF-b, MDNCF-c, Monocyte-derived neutrophil chemotactic factor, Monocyte-derived neutrophil-activating peptide, Neutrophil activating peptide 1, Neutrophil activating protein 1, Neutrophil-activating factor, Neutrophil-activating protein 1, Protein 3 10C, Protein 3-10C, SCYB8, Small inducible cytokine subfamily B member 8, T cell chemotactic factor, T-cell chemotactic factor, TSG1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\" width=\"170\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eE.coli\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eSer 28-Ser 99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eNP_000575.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003e8.5 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eNone\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.3549%;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 62.2761%;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv class=\"dt01 detail_section\" id=\"dt_tab2\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 305.5px;\" data-mce-style=\"width: 100%; height: 305.5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 24.2755%;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 75.3555%;\"\u003e\u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 24.2755%;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 75.3555%;\"\u003ePlease contact us for more information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\" data-mce-style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 24.2755%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 75.3555%;\"\u003eGenerally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 24.2755%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 75.3555%;\"\u003eThis product is provided as lyophilized powder which is shipped with ice packs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 97.9688px;\" data-mce-style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 24.2755%;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 75.3555%;\"\u003eLyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 50.7812px;\" data-mce-style=\"height: 50.7812px;\"\u003e\n\u003ctd style=\"width: 24.2755%;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 75.3555%;\"\u003ePlease refer to the printed manual for detailed information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003ch3\u003e\n\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003ch3\u003e\u003cspan class=\"title\"\u003eBackground\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003eInterleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte\/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia\/anoxia may stimulate expression. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8\/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental chang. Numerous observations have established IL-8\/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. The discovery of these biological functions suggests that IL-8\/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"100μg","offer_id":40692708343866,"sku":"PKSH030277-100","price":856.95,"currency_code":"USD","in_stock":true},{"title":"20μg","offer_id":40692708376634,"sku":"PKSH030277-20","price":339.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/recombinant-human-il-8-cxcl8-protein-e-coli-100-g-elabscience-biotechnology-cell-assays-22373181521978.jpg?v=1752498195","url":"https:\/\/www.msesupplies.com\/en-de\/products\/recombinant-human-il-8-cxcl8-protein-e-coli","provider":"MSE Supplies","version":"1.0","type":"link"}