{"product_id":"recombinant-human-il-23-il23a-il12b-heterodimer-protein-his-tag-active","title":"Recombinant Human IL-23(IL23A\u0026IL12B Heterodimer) Protein (His Tag)(Active)","description":"\u003ch2\u003eRecombinant Human IL-23(IL23A\u0026amp;IL12B Heterodimer) Protein (His Tag)(Active)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 29.5938px;\" data-mce-style=\"height: 29.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\" data-mce-style=\"height: 10px;\"\u003e\n\u003ctd width=\"137\" style=\"width: 164.547px; height: 10px;\" data-mce-style=\"width: 164.547px; height: 10px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"106\" style=\"height: 10px; width: 367.453px;\"\u003ePKSH030445\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" data-mce-style=\"width: 164.547px; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 367.453px; height: 19.5938px;\"\u003e\u003cspan\u003eHEK293 Cells\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\" data-mce-style=\"font-size: 0.875rem;\"\u003eDescription   \u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab1\"\u003e\n\u003ctable style=\"width: 104.745%; height: 382.281px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 39.1875px;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 39.1875px;\"\u003eCLMF p40, IL-12 subunit p40, IL-23, IL-23A, IL-23p19, IL23P19, NKSF2, P19, SGRF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 19.5938px;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 19.5938px;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 19.5938px;\" width=\"170\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 19.5938px;\"\u003eHEK293 Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 19.5938px;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 19.5938px;\"\u003eMet 1-Pro189\u0026amp;Met 1-Ser 28\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 19.5938px;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 19.5938px;\"\u003eQ9NPF7\u0026amp;NP_002178.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 19.5938px;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 19.5938px;\"\u003e20.1\u0026amp;36.2 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 19.5938px;\"\u003eObserved Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 19.5938px;\"\u003e22\u0026amp;45 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 10px;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 10px;\"\u003eC-His\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 215.531px;\"\u003e\n\u003ctd style=\"width: 41.8591%; height: 215.531px;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 57.7888%; height: 215.531px;\"\u003e1. Measured by its ability to bind biotinylated recombinant human IL12RB1 in a functional ELISA. 2. Immobilized human IL23A-His+IL12B-His at 10 μg\/ml (100 μl\/well) can bind human IL23R-Fc. The EC50 of human IL23R-Fc is 0.28-0.66 μg\/ml. 3. Immobilized human IL23A-His+IL12B-His at 10 μg\/ml (100 μl\/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.14-0.35 μg\/ml. 4. Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng\/mL.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv class=\"dt01 detail_section\" id=\"dt_tab2\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 305.5px;\" data-mce-style=\"width: 100%; height: 305.5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 26.1003%; height: 19.5938px;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 73.5307%; height: 19.5938px;\"\u003e\u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 26.1003%; height: 39.1875px;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 73.5307%; height: 39.1875px;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\" data-mce-style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 26.1003%; height: 78.375px;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 73.5307%; height: 78.375px;\"\u003eGenerally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 26.1003%; height: 39.1875px;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 73.5307%; height: 39.1875px;\"\u003eThis product is provided as lyophilized powder which is shipped with ice packs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 97.9688px;\" data-mce-style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 26.1003%; height: 97.9688px;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 73.5307%; height: 97.9688px;\"\u003eLyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 50.7812px;\" data-mce-style=\"height: 50.7812px;\"\u003e\n\u003ctd style=\"width: 26.1003%; height: 10px;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 73.5307%; height: 10px;\"\u003ePlease refer to the printed manual for detailed information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eBackground\u003c\/span\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003eInterleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"100μg","offer_id":40695695999034,"sku":"PKSH030445-100","price":1301.95,"currency_code":"USD","in_stock":true},{"title":"5μg","offer_id":40695696031802,"sku":"PKSH030445-5","price":151.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/imy94K_e355ac3c-f76f-410b-a029-31fc4d2b208b.jpg?v=1729838648","url":"https:\/\/www.msesupplies.com\/en-de\/products\/recombinant-human-il-23-il23a-il12b-heterodimer-protein-his-tag-active","provider":"MSE Supplies","version":"1.0","type":"link"}