{"product_id":"recombinant-human-csf1r-cd115-protein-his-gst-tag","title":"Recombinant Human CSF1R\/CD115 Protein (His \u0026 GST Tag)","description":"\u003ch2\u003eRecombinant Human CSF1R\/CD115 Protein (His \u0026amp; GST Tag)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 39.1876px;\" width=\"503\" data-mce-style=\"height: 29.5938px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 10px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" width=\"137\" data-mce-style=\"width: 164.547px; height: 10px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 19.5938px; width: 367.453px;\" width=\"106\" class=\"xl65\" height=\"38\"\u003ePKSH030422\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 164.547px; height: 19.5938px;\" data-mce-style=\"width: 164.547px; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 367.453px; height: 19.5938px;\" data-mce-style=\"width: 367.453px; height: 19.5938px;\"\u003e\u003cspan\u003eBaculovirus-Insect Cells\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\" data-mce-style=\"font-size: 0.875rem;\"\u003eDescription   \u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab1\" class=\"dt01\"\u003e\n\u003ctable class=\"pro-table\" style=\"width: 104.745%; height: 225.532px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 78.375px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 37.9509%; height: 78.375px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 78.375px;\"\u003eC-FMS, CD115, CSF-1 receptor, CSF-1-R, CSF-1R, CSF1R, FIM2, FMS, HDLS, M-CSF-R, MCSF Receptor , Macrophage colony-stimulating factor 1 receptor, Proto-oncogene c-Fms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.9509%; height: 19.5938px;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 19.5938px;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 37.9509%; height: 19.5938px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 19.5938px;\"\u003eBaculovirus-Insect Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.9509%; height: 19.5938px;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 19.5938px;\"\u003eLys 543-Cys 972\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.9509%; height: 19.5938px;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 19.5938px;\"\u003eNP_005202.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.9509%; height: 19.5938px;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 19.5938px;\"\u003e76 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.9509%; height: 19.5938px;\"\u003eObserved Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 19.5938px;\"\u003e75 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 37.9509%; height: 19.5938px;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 19.5938px;\"\u003eN-His-GST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"width: 37.9509%; height: 10px;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 61.697%; height: 10px;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n  \u003c\/div\u003e\n\u003cdiv id=\"dt_tab2\" class=\"dt01 detail_section\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eProperties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 215.531px;\" class=\"dtl_table\" data-mce-style=\"width: 100%; height: 305.5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.8448%; height: 19.5938px;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 68.7862%; height: 19.5938px;\"\u003e\u0026gt; 82 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 30.8448%; height: 39.1875px;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 68.7862%; height: 39.1875px;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 78.375px;\"\u003e\n\u003ctd style=\"width: 30.8448%; height: 39.1875px;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.7862%; height: 39.1875px;\"\u003eStore at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 58.7812px;\" data-mce-style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 30.8448%; height: 58.7812px;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.7862%; height: 58.7812px;\"\u003eThis product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\" data-mce-style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 30.8448%; height: 39.1875px;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 68.7862%; height: 39.1875px;\"\u003eSupplied as sterile solution of 50mM Tris, 150mM NaCl, pH 7.4, 20% glycerol, 0.3mM DTT\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\" data-mce-style=\"height: 50.7812px;\"\u003e\n\u003ctd style=\"width: 30.8448%; height: 19.5938px;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 68.7862%; height: 19.5938px;\"\u003eNot Applicable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\u003cstrong\u003e\u003cspan class=\"title\"\u003eBackground\u003c\/span\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003e\n\u003cstrong\u003e\u003cspan class=\"title\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dt01\"\u003eM-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to \u0026amp;quot;autophosphorylation\u0026amp;quot; of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1\/CSF1R in normal mammary gland development is very intriguing because this receptor\/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"50μg","offer_id":40695112761402,"sku":"PKSH030422-50","price":848.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/recombinant-human-csf1r-cd115-protein-his-gst-tag-50-g-elabscience-biotechnology-cell-assays-22377811312698.jpg?v=1752498943","url":"https:\/\/www.msesupplies.com\/en-de\/products\/recombinant-human-csf1r-cd115-protein-his-gst-tag","provider":"MSE Supplies","version":"1.0","type":"link"}