{"product_id":"recombinant-2019-ncov-guanine-n7_meth-protein-his-tag","title":"Recombinant 2019-nCoV Guanine-N7_meth Protein (His Tag)","description":"\u003ch2\u003eRecombinant 2019-nCoV Guanine-N7_meth Protein (His Tag)\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 76px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 38px;\"\u003e\n\u003ctd style=\"height: 38px; width: 137.047px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 38px; width: 396.953px;\" width=\"106\" class=\"xl65\" height=\"38\"\u003ePKSR030473\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 38px;\"\u003e\n\u003ctd style=\"height: 38px; width: 137.047px;\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"height: 38px; width: 396.953px;\" width=\"106\" class=\"xl65\" height=\"38\"\u003e\u003cspan\u003eE.coli\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eDescription\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"dtl_table\" style=\"width: 100%; height: 289.484px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 35.1875px;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 35.1875px;\"\u003eGuanine-N7 methyltransferase, SARS-CoV 2 ExoN, SARS-CoV 2 nsp14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 19.5938px;\"\u003eSpecies\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 19.5938px;\"\u003eSARS-CoV-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 35.1875px;\" width=\"170\"\u003eExpression Host\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 35.1875px;\"\u003eE.coli\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 19.5938px;\"\u003eSequence\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 19.5938px;\"\u003eAla1-Gln527\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 31.1875px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 31.1875px;\"\u003eAccession\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 31.1875px;\"\u003eYP_009725309.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 54.7656px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 54.7656px;\"\u003eCalculated Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 54.7656px;\"\u003e62.9 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 39.1875px;\"\u003eObserved Molecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 39.1875px;\"\u003e60 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 35.1875px;\"\u003eTag\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 35.1875px;\"\u003eN-His\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.9853%; height: 19.5938px;\"\u003eBio-activity\u003c\/td\u003e\n\u003ctd style=\"width: 67.6471%; height: 19.5938px;\"\u003eNot validated for activity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProperties\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 266.313px;\" class=\"dtl_table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003e\u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 74.375px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003eStore at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003eThis product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 74.375px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eFormulation\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003eSupplied as a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, 2mM DTT, 20% Glycerol, 0.1% TritonX-100, pH 6.0.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 17.0956%;\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd style=\"width: 82.5368%;\"\u003eNot Applicable\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv class=\"dt01\" id=\"dt_tab3\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\n\u003cdiv id=\"dt_tab3\" class=\"dt01\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"clearfix\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"clearfix\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"clearfix\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"clearfix\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"clearfix\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"clearfix\"\u003eThe nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.\u003c\/div\u003e\n\u003cdiv id=\"dt_tab_citation\" class=\"dt01\"\u003e\u003c\/div\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"50μg","offer_id":40831779831866,"sku":"PKSR030473-50","price":653.95,"currency_code":"USD","in_stock":true},{"title":"10μg","offer_id":40831779864634,"sku":"PKSR030473-10","price":248.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/recombinant-2019-ncov-guanine-n7_meth-protein-his-tag-50-g-elabscience-biotechnology-cell-assays-22843984511034.jpg?v=1752497501","url":"https:\/\/www.msesupplies.com\/en-de\/products\/recombinant-2019-ncov-guanine-n7_meth-protein-his-tag","provider":"MSE Supplies","version":"1.0","type":"link"}