{"product_id":"phospho-catenin-beta-tyr654-polyclonal-antibody","title":"Phospho-Catenin Beta (Tyr654) Polyclonal Antibody","description":"\u003ch2\u003ePhospho-Catenin Beta (Tyr654) Polyclonal Antibody\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 68.7814px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"height: 10px; width: 156.719px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 387.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-20830\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman,  Mouse,  Rat\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\" width=\"170\"\u003e\u003cspan\u003eRabbit\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eWB,  IHC-p\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 99.8182%; height: 535.735px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eHuman,  Mouse,  Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eWB,  IHC-p\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eSynthesized peptide derived from human Catenin-β around the phosphorylation site of Tyr654\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 51.9688px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003e88kDa,  Beta catenin,  Beta-catenin,  CATNB,  CHBCAT,  CTNB1,  CTNNB,  CTNNB1,  Cadherin associated protein,  Catenin (cadherin associated protein),  Catenin beta 1,  Catenin beta-1,  DKFZp686D02253,  FLJ25606,  FLJ37923,  OTTHUMP00000162082,  OTTHUMP0000016522,  OTTHUMP00000165222,  beta 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 23.5469px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"P35222\" href=\"https:\/\/www.uniprot.org\/uniprot\/P35222\" target=\"_blank\"\u003eP35222\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003e85 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003e75 kDa\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eCytoplasm. Nucleus. Cytoplasm\u0026gt;cytoskeleton. Cell junction\u0026gt;adherens junction. Cell junction. Cell membrane. Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 20.9688px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eTissue Specificity\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eExpressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eCancer,  Cardiovascular,  Neuroscience,  Signal Transduction,  Stem Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"170\" style=\"width: 10.5956%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 89.2568%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 62.3126px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 23.125px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 23.125px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 23.125px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.4596%; height: 19.5938px;\"\u003eWB\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%; height: 19.5938px;\"\u003e1:500-1:2000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.4596%;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%;\"\u003e1:100-1:300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e   \u003c\/p\u003e\n\u003cp\u003eKey dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF\/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin\/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.\u003cbr\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40886287368250,"sku":"E-AB-20830-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40886287401018,"sku":"E-AB-20830-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40886287433786,"sku":"E-AB-20830-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40886287466554,"sku":"E-AB-20830-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-20830-1.jpg?v=1748414232","url":"https:\/\/www.msesupplies.com\/en-de\/products\/phospho-catenin-beta-tyr654-polyclonal-antibody","provider":"MSE Supplies","version":"1.0","type":"link"}