{"product_id":"nuak1-polyclonal-antibody-store-at-20-c","title":"NUAK1 Polyclonal Antibody Store at -20°C","description":"\u003ch2\u003eNUAK1 Polyclonal Antibody Store at -20°C\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 69.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd width=\"137\" style=\"height: 10px; width: 156.719px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"102\" style=\"height: 10px; width: 387.281px;\"\u003eE-AB-12986\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eHuman, Mouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 20.5938px;\"\u003e\n\u003ctd style=\"height: 20.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 20.5938px;\"\u003e\u003cspan\u003eIHC\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pro-table\" style=\"width: 99.8182%; height: 519.032px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003eHuman, Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003eIHC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003eSynthetic peptide of human NUAK1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003eNUAK1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 97.9688px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 97.9688px;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 97.9688px;\"\u003eAMP activated protein kinase family member 5,  AMPK related protein kinase 5,  AMPK-related protein kinase 5,  NUAK family SNF1 like kinase,  NUAK family SNF1-like kinase 1,  NUAK1,  Nuak1,  Omphalocele kinase 1,  Probable serine\/threonine protein kinase KIAA0537\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003e\n\u003cdiv\u003e\u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/O60285\" title=\"O60285\" class=\"text-primary mr-2\" target=\"_blank\"\u003eO60285\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 39.1875px;\" width=\"170\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 39.1875px;\"\u003eCytoskeleton, microtubule cytoskeleton, Nucleus, fibrillar center, nucleoplasm, nucleus, Other locations: cytoplasm.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003e0.6 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 39.1875px;\" width=\"170\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 39.1875px;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 35.1875px;\" width=\"170\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 35.1875px;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 33.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 33.1875px;\" width=\"170\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 33.1875px;\"\u003eCancer,  Signal Transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 19.5938px;\" width=\"170\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 19.5938px;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 39.1875px;\" width=\"170\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 39.1875px;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%; height: 39.1875px;\" width=\"170\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%; height: 39.1875px;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 40.9376px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 33.3097%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 66.3293%; height: 19.5938px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21.3438px;\"\u003e\n\u003ctd style=\"width: 33.3097%; height: 21.3438px;\"\u003e\u003cspan\u003eIHC\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 66.3293%; height: 21.3438px;\"\u003e\u003cspan\u003e1:25-1:100\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene. Serine\/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53\/TP53.Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability.Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex.Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.\u003c\/span\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40869618286650,"sku":"E-AB-12986-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40869618319418,"sku":"E-AB-12986-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40869618352186,"sku":"E-AB-12986-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40869618384954,"sku":"E-AB-12986-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/nuak1-polyclonal-antibody-store-at-20-c-200-l-elabscience-biotechnology-biomarkers-22939878031418.jpg?v=1752499936","url":"https:\/\/www.msesupplies.com\/en-de\/products\/nuak1-polyclonal-antibody-store-at-20-c","provider":"MSE Supplies","version":"1.0","type":"link"}