{"product_id":"nlrp3-polyclonal-antibody","title":"NLRP3 Polyclonal Antibody","description":"\u003ch2\u003eNLRP3 Polyclonal Antibody\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 96.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 38px;\"\u003e\n\u003ctd width=\"137\" style=\"height: 38px; width: 214.5px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"102\" style=\"height: 28.5pt; width: 329.5px;\"\u003eE-AB-93354\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 214.5px; height: 19.5938px;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 329.5px; height: 19.5938px;\"\u003e\u003cspan\u003eMouse, Rat\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 214.5px; height: 19.5938px;\" width=\"170\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 329.5px; height: 19.5938px;\"\u003e\u003cspan\u003eRabbit\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 214.5px; height: 19.5938px;\"\u003e\u003cspan\u003eApplications\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 329.5px; height: 19.5938px;\"\u003e\u003cspan\u003eWB, IF\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 482.001px;\" class=\"dtl_table2\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eHuman, Mouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eWB, IF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 27.75px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eRecombinant fusion protein of mouse NLRP3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eNLRP3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eAGTAVPRL,  AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCAS1, FCU, KEFH, MWS, NALP3, PYPAF1, AII\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"Q8R4B8\" href=\"https:\/\/www.uniprot.org\/uniprot\/Q8R4B8\" target=\"_blank\"\u003eQ8R4B8\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 31.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003e110 kDa\n\u003cdiv class=\"position-relative\"\u003e\u003ca class=\"text-secondary\" aria-controls=\"collapseMW\" aria-expanded=\"true\" href=\"https:\/\/www.elabscience.com\/p\/nlrp3-polyclonal-antibody--e-ab-93354#collapseMW\" data-toggle=\"collapse\" role=\"button\" target=\"_blank\"\u003e\u003ci aria-hidden=\"true\" class=\"iconfont icon-question-circle fs_16\"\u003e\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eThe actual band is not consistent with the expectation.\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eCytoplasm, cytosol, endoplasmic reticulum, extracellular region, inflammasome complex, NLRP3 inflammasome complex, nucleus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4079%;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.231%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 81.9689px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 27.0758%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 72.5632%; height: 19.5938px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 27.0758%; height: 19.5938px;\"\u003e\u003cspan\u003eWB\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 72.5632%; height: 19.5938px;\"\u003e\u003cspan\u003e1:500-1:2000\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 27.0758%; height: 19.5938px;\"\u003e\u003cspan\u003eIF\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 72.5632%; height: 19.5938px;\"\u003e\u003cspan\u003e1:50-1:200\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD\/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40869447499834,"sku":"E-AB-93354-200","price":677.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40869447532602,"sku":"E-AB-93354-120","price":488.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40869447565370,"sku":"E-AB-93354-60","price":380.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-93354.jpg?v=1746996926","url":"https:\/\/www.msesupplies.com\/en-de\/products\/nlrp3-polyclonal-antibody","provider":"MSE Supplies","version":"1.0","type":"link"}