{"product_id":"jak2-polyclonal-antibody-reactivity-human","title":"JAK2 Polyclonal Antibody Reactivity Human","description":"\u003ch2\u003eJAK2 Polyclonal Antibody Reactivity Human\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"height: 71.7814px;\" width=\"503\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10px;\"\u003e\n\u003ctd style=\"height: 10px; width: 156.719px;\" width=\"137\"\u003eSKU #\u003c\/td\u003e\n\u003ctd style=\"height: 10px; width: 387.281px;\" width=\"102\" class=\"xl65\" height=\"38\"\u003eE-AB-31844\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003eHuman, \u003cspan\u003eMouse, Rat\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 22.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 22.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eWB, IHC-p, IF\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 99.8214%; height: 529.032px;\" class=\"pro-table\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eWB, IHC-p, IF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 39.1875px;\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 39.1875px;\"\u003eSynthesized peptide derived from human JAK2 around the non-phosphorylation site of Tyr1007.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eJAK2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 78.375px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 78.375px;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 78.375px;\"\u003eJAK 2,  JAK-2,  JAK2,  JTK 10,  JTK10,  Janus Activating Kinase 2,  Janus kinase 2,  Janus kinase 2 (a protein tyrosine kinase),  OTTHUMP00000043260,  THCYT3,  Tyrosine protein kinase JAK2,  Tyrosine-protein kinase JAK2,  kinase Jak2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003e\n\u003cdiv\u003e\u003ca class=\"text-primary mr-2\" title=\"O60674\" href=\"https:\/\/www.uniprot.org\/uniprot\/O60674\" target=\"_blank\"\u003eO60674\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eCalculated MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003e131 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003e130 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eEndomembrane system. Nucleus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 39.1875px;\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 39.1875px;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eAffinity purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 39.1875px;\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 39.1875px;\"\u003eCancer, Cell biology, Epigenetics and Nuclear Signaling, Signal transduction\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 19.5938px;\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 19.5938px;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 39.1875px;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 39.1875px;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd width=\"170\" style=\"width: 31.4656%; height: 39.1875px;\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.1755%; height: 39.1875px;\"\u003eThe product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 62.3438px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 21.375px;\"\u003e\n\u003ctd style=\"width: 35.3791%; height: 21.375px;\" class=\"bold\" width=\"30%\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 64.2599%; height: 21.375px;\" class=\"bold\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21.375px;\"\u003e\n\u003ctd style=\"width: 35.3791%; height: 21.375px;\"\u003eWB\u003c\/td\u003e\n\u003ctd style=\"width: 64.2599%; height: 21.375px;\"\u003e1:500-1:2000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 35.3791%; height: 19.5938px;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 64.2599%; height: 19.5938px;\"\u003e1:100-1:300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.3791%;\"\u003eIF\u003c\/td\u003e\n\u003ctd style=\"width: 64.2599%;\"\u003e1:50-1:200\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNon-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), granulocyte-macrophage colony-stimulating factor (CSF2), thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity). Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40876756369466,"sku":"E-AB-31844-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40876756402234,"sku":"E-AB-31844-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40876756435002,"sku":"E-AB-31844-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40876756467770,"sku":"E-AB-31844-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/Elabscience_6fd317fa-089e-4bd5-b1cf-f8ae8fbd9a0b.jpg?v=1747824552","url":"https:\/\/www.msesupplies.com\/en-de\/products\/jak2-polyclonal-antibody-reactivity-human","provider":"MSE Supplies","version":"1.0","type":"link"}