{"product_id":"gsk3-beta-monoclonal-antibody-store-at-20-c-host-mouse","title":"GSK3 Beta Monoclonal Antibody Store at -20°C Host Mouse","description":"\u003ch2\u003eGSK3 Beta Monoclonal Antibody Store at -20°C Host Mouse\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable width=\"503\" style=\"height: 72.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 14px;\"\u003e\n\u003ctd width=\"137\" style=\"height: 14px; width: 156.719px;\"\u003eSKU #\u003c\/td\u003e\n\u003ctd height=\"38\" class=\"xl65\" width=\"102\" style=\"height: 14px; width: 387.281px;\"\u003eE-AB-22130\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eReactivity\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan class=\"cat reg_tag\"\u003e\u003cspan\u003eHuman,  Mouse,  Rat\u003c\/span\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 156.719px; height: 19.5938px;\"\u003e\u003cspan\u003eHost\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eMouse\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"height: 19.5938px; width: 156.719px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 387.281px; height: 19.5938px;\"\u003e\u003cspan\u003eWB,  IHC-p\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"pro-table\" style=\"width: 99.8182%; height: 512.391px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eIsotype\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eHost\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eReactivity\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eHuman,  Mouse,  Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eApplications\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eWB,  IHC-p\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eClonality\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eMonoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eImmunogen\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eSynthetic Peptide of GSK3β\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eAbbre\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eGSK3 beta\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 34.5469px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eGSK 3 beta,  GSK-3 beta,  GSK3B,  GSK3beta isoform,  Glycogen Synthase Kinase 3 Beta,  Glycogen synthase kinase-3 beta,  Serine\/threonine-protein kinase GSK3B\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eSwissprot\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e\n\u003cdiv\u003e\u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/P49841\" title=\"P49841\" class=\"text-primary mr-2\" target=\"_blank\"\u003eP49841\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eObserved MW\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e46 kDa\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eCellular Localization\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eCytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eTissue Specificity\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eExpressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eConcentration\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eBuffer\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003ePhosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003ePurification Method\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eProtein A purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eResearch Areas\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eCancer,  Cardiovascular,  Metabolism,  Neuroscience,  Signal Transduction,  Stem Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eClone No.\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003e4C3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eConjugation\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eStore at -20°C Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.4665%;\" width=\"170\"\u003eShipping\u003c\/td\u003e\n\u003ctd style=\"width: 68.1775%;\"\u003eThe product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated Reagents\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 58.7814px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd width=\"30%\" class=\"bold\" style=\"width: 35.4596%; height: 19.5938px;\"\u003eApplications\u003c\/td\u003e\n\u003ctd class=\"bold\" style=\"width: 64.1793%; height: 19.5938px;\"\u003eRecommended Dilution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.4596%;\"\u003eWB\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%;\"\u003e1:1000-2000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.4596%;\"\u003eIHC\u003c\/td\u003e\n\u003ctd style=\"width: 64.1793%;\"\u003e1:100-200\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eParticipates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1\/beta-catenin. Phosphorylates CTNNB1\/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.\u003cbr\u003e\u003c\/p\u003e","brand":"Elabscience Biotechnology","offers":[{"title":"200μL","offer_id":40879510356026,"sku":"E-AB-22130-200","price":559.95,"currency_code":"USD","in_stock":true},{"title":"120μL","offer_id":40879510388794,"sku":"E-AB-22130-120","price":416.95,"currency_code":"USD","in_stock":true},{"title":"60μL","offer_id":40879510421562,"sku":"E-AB-22130-60","price":328.95,"currency_code":"USD","in_stock":true},{"title":"20μL","offer_id":40879510454330,"sku":"E-AB-22130-20","price":265.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0722\/7785\/files\/E-AB-22130-3.jpg?v=1748070776","url":"https:\/\/www.msesupplies.com\/en-de\/products\/gsk3-beta-monoclonal-antibody-store-at-20-c-host-mouse","provider":"MSE Supplies","version":"1.0","type":"link"}