Surface Functionalized Superparamagnetic Iron Oxide Nanoparticle (SPION) High Concentration Suspension

Surface Functionalized Superparamagnetic Iron Oxide Nanoparticle (SPION) High Concentration Suspension

MSE Supplies offers Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoparticle Suspension with different functionalization on the surface. SPIONs consist of cores made of iron oxides that can be targeted to the required area through external magnets. They show interesting properties such as superparamagnetism, high field irreversibility, high saturation field, extra anisotropy contributions or shifted loops after field cooling. The SPIONs would not show magnetic interaction after the external magnetic field is removed which make them popular as microcarrier in drug delivery applications. SPIONs typically have a magnetic particle core coated with a biocompatible polymer. The coating acts to shield the magnetic particle from the surrounding environment and can also be functionalized by attaching carboxyl groups, biotin, avidin, carbodiimide and other molecules in order to increase the targeting yield. These molecules then act as attachment points for the coupling of cytotoxic drugs or target antibodies to the carrier complex. Due to their easy synthesis, biocompatibility, multifunctionality, and possibility of further surface modification with various chemical agents, SPIONs could support many other fields of medicine, such as Magnetic Resonance Imaging (MRI), Myocardial perfusion imaging (MPI) and magnetic hyperthermia.

Technical Data

For different particle sizes, coating and suspension liquid, please contact us.

References:

1. Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. Advanced drug delivery reviews 63, no. 1-2 (2011): 24-46.

2. Superparamagnetic iron oxide nanoparticles—Current and prospective medical applications. Materials 12, no. 4 (2019): 617.

3. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. European radiology 11, no. 11 (2001): 2319-2331.